Take a 10-night trip to the Patagonia region of South America. Start in Buenos Aires, where you visit the Plaza de Mayo and the Plaza del Congreso. From there, fly to Ushuaia, the world’s southernmost city, where you board the MV Stella Australis on your voyage to Cape Horn. Sail through Beagle and Murray channels to disembark in Cape Horn National Park and see the scenic beauty near Antarctica. Disembark in historic Wululaia Bay. Also, visit Gunther Pluschow Glacier and Magdalena Island before disembarking at Punta Arenas and flying to Santiago for a tour on your way back to the US. Starting from $4835, including air, with seasonal departures.